Avoid or Use Alternate Drug. Intravenous iron sucrose: establishing a safe dose - PubMed Otherwise, call a poison control center right away. Mean change in Hgb from baseline to Week 5 2,5 Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. Use Caution/Monitor. Divide the calculated dose by the patient's weight (IBW if BMI >30, or actual body weight (ABW) if BMI30) to ensure it does NOT exceed 20mg/kg. Maximum recommended single dose: 300 mg (See Prescriber's Orders). Applies only to oral form of both agents. Bhowmik D, Modi G, Ray D, Gupta S, Agarwal SK, Tiwari SC, Dash SC. Contraindicated. Most reactions associated with intravenous iron preparations occur within 30 minutes of the completion of the infusion. Am J HealthSyst Pharm 2006;63:731735. Iron Sucrose Protocol - Cmqcc Monitor Closely (1)deferoxamine decreases levels of iron sucrose by inhibition of GI absorption. Hanson DB, Hendeles L. Guide to total dose intravenous iron dextran therapy. Feraheme, when added to intravenous infusion bags containing either 0.9% Sodium Chloride Injection, USP (normal saline), or 5% Dextrose Injection, USP, at concentrations of 2-8 mg elemental iron per mL, should be used immediately but may be stored at controlled room temperature (25C 2C) for up to 4 hours or refrigerated (2-8 C) for up to 48 hours. Many people using this medication do not have serious side effects.Severe dizziness or fainting (hypotension) may occur while you are receiving IV iron. Most Monitor Closely (1)iron sucrose will decrease the level or effect of sarecycline by inhibition of GI absorption. Included in the iron dextran package insert. Immune system disorders: Anaphylactic-type reactions, angioedema, Nervous system disorders: Convulsions, collapse, light-headedness, loss-of-consciousness, Respiratory, thoracic and mediastinal disorders: Bronchospasm, dyspnea, Musculoskeletal and connective tissue disorders: Back pain, swelling of the joints, General disorders and administration site conditions: Hyperhidrosis, Published studies on intravenous iron sucrose treatment after first trimester of pregnancy not shown adverse maternal or fetal outcomes; available reports of intravenous iron sucrose use in pregnant women during first trimester are insufficient to assess risk of major birth defects and miscarriage; iron deficiency anemia during pregnancy should be treated because there are risks to mother and fetus associated with untreated iron deficiency anemia (IDA) in pregnancy; risks to fetus associated with maternal severe hypersensitivity reactions, Severe adverse reactions including circulatory failure (severe hypotension, shock including in the context of anaphylactic reaction) may occur in pregnant women with parenteral iron products which may cause fetal bradycardia, especially during second and third trimester, Iron sucrose is present in human milk, and available published reports following exposure to 100-300 mg intravenous iron sucrose have not reported adverse reactions in breastfed infants; there are no data on effects on milk production, Developmental and health benefits of breastfeeding should be considered, along with mothers clinical need for treatment and any potential adverse effects on breastfed child from therapy or from underlying maternal condition. Treatment of anemia due to iron deficiency. Venofer (Iron Sucrose Injection): Uses, Dosage, Side Effects - RxList Avoid or Use Alternate Drug. Serious - Use Alternative (1)iron sucrose decreases levels of fleroxacin by inhibition of GI absorption. ]Venofer treatment may be repeated if iron deficiency reoccurs. Recommended starting dose 1 Aranesp is dosed at 2.25 mcg/kg SC QW or 500 SC Q3W 1 (SC = subcutaneous) Before initiating 1: Evaluate iron status; administer supplemental iron therapy as needed Correct or eliminate other causes of anemia Initiate 1: Only when Hb < 10 g/dL It is important to note that the above calculations merely provide estimates and that individual dosage should be established by a medical professional based on the current package insert for the elemental iron product used. Use Caution/Monitor. Brand name: Venofer Drug class: Iron Preparations Chemical name: iron saccharate CAS number: 8047-67-4 Medically reviewed by Drugs.com on Oct 25, 2022. Chandler G, Harchowel J, Macdougall I. 2 DOSAGE AND ADMINISTRATION 2.1 Recommended Dosage Recommended dosage for patients weighing 50kg (110lb) or more: Give Injectaferin two doses separated by at least 7 days. Iron deficiency anemia calculator (diagnosis), Iron deficiency anemia vs. Patients measured hemoglobin can be input in g/dL or mmol/L. Use Caution/Monitor. Minor (2)calcium acetate decreases levels of iron sucrose by inhibition of GI absorption. Slow or stop the infusion if adverse reactions occur. Use Caution/Monitor. Ganzoni AM. Applies only to oral form of both agents. Dose administration to an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal or cardiac function, and of concomitant disease or other drug therapy. Venofer treatment may be repeated if iron deficiency reoccurs. Injection site discoloration has been reported following extravasation. Read our. Interaction only with oral iron administration. feasible, Maximum total cumulative iron sucrose dose administered in 14 days is 1000 mg elemental iron. 2012;2(4):288-335. Due Date form Ultrasound Report. Oral iron therapy is the first method while IV therapy comes in place when there are contraindications or the body doesnt respond to the oral one. Intravenous iron-dextran: therapeutic and experimental possibilities. Venofer must only be administered intravenously either by slow injection or by infusion. Serious - Use Alternative (1)iron sucrose decreases levels of levofloxacin by inhibition of GI absorption. Many patients with kidney disease cannot get enough iron from food and require injections. iron sucrose decreases levels of manganese by inhibition of GI absorption. Calculosaurus | Medical calculators for obstetrics and gynaecology Use the menu to browse through our clinical calculators. Iron sucrose | Drugs | BNF | NICE Access your plan list on any device mobile or desktop. IDA diagnosis is based on full blood examination and on the serum ferritin level. After administration of iron dextran complex, evidence of a therapeutic response can be seen in a few days as an increase in the reticulocyte count. Contact the applicable plan calcium citrate decreases levels of iron sucrose by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown. Applies only to oral form of both agents. IV iron sucrose (Venofer) given as divided dosages, and low molecular weight iron dextran (CosmoFer) this can be given as divided dose or as a total dose infusion . Administer on 5 different occasions over a 14 day period. Each mL contains 20 mg of elemental iron. Avoid or Use Alternate Drug. Intravenous Iron Therapy in Patients with Iron Deficiency Anemia This iron deficiency calculator determines the iron deficit based on patient weight, hemoglobin and iron stores to prepare for iron replacement. Use Caution/Monitor. The normal ranges are: for males 13.8 to 18.0 g/dL (138 to 180 g/L, or 8.56 to 11.17mmol/L) and for females 12.1 to 15.1 g/dL (121 to 151 g/L, or 7.51 to 9.37mmol/L). Minor/Significance Unknown. On the other hand, slow decreases, such as that in chronic occult gastrointestinal bleeding are often difficult to diagnose. 20 mg/mL for Iron sucrose; 5 mg/mL for Ferric gluconate. commonly, these are "non-preferred" brand drugs or specialty Modify Therapy/Monitor Closely. 1970; 100(7):301-3. Minor/Significance Unknown.iron sucrose increases levels of calcium chloride by enhancing GI absorption. No data are available regarding overdosage of Venofer in humans. Avoid or Use Alternate Drug. Separate by 2 hr. Slowing the infusion rate may alleviate symptoms. FOR PATIENTS WEIGHING LESS THAN 50 kg: Administer Monoferric as 20 mg/kg actual body weight by intravenous infusion 20 minutes . Most Where C= concentration of elemental iron (mg/ml) in the product being used: Data from Ferrlecit postmarketing spontaneous reports indicate that individual doses exceeding 125 mg may be associated with a higher incidence and/or severity of adverse events, Adult Patients with Hemodialysis Dependent-Chronic Kidney Disease (HDD-CKD), Adult Patients with Non-Dialysis Dependent-Chronic Kidney Disease (NDD-CKD), WARNING: RISK FOR SERIOUS HYPERSENSITIVITY/ANAPHYLAXIS REACTIONS, Iron Deficiency and Anemia- signs and therapeutic options. Aranesp (darbepoetin alfa) | Dosing Considerations Can't find what you need? Consult your doctor for more details.Remember that it is best to get your vitamins and minerals from food whenever possible. Applies only to oral form of both agents. Anemia; 2015: 763576. Venofer is manufactured under license from Vifor (International) Inc., Switzerland. Applies only to oral form of both agents. Intravenous iron sucrose for children with iron deficiency anemia: a Serious - Use Alternative (1)iron sucrose decreases levels of ciprofloxacin by inhibition of GI absorption. Crown Rump Length and Nuchal Translucency. Administer Venofer early during the dialysis session (generally within the first hour). Applies only to oral form of both agents. Last updated on Jun 1, 2022. Schweiz Med Wochenschr; 100(7):301-3. Applies only to oral form of both agents. Equations : Total body iron deficit (mg) = body weight (kg) x (target Hb - actual Hb in g/dL) x 2.4 + iron depot (mg)** [1, 2] Iron depot: 15 mg/kg for body weight less than 35 kg 500 mg for those with a body weight greater than or equal to 35 kg Ideal Body Weight (kg) =45.5 +2.3 * (height inches - 60 inches) [3] Intravenous iron sucrose: establishing a safe dose. Avoid or Use Alternate Drug. This calculator will help pinpoint potential causes of anemia based on Since this is less than the threshold of total dose of 20 mg/kg, the deficit can be eliminated with a single infusion. Minor/Significance Unknown. We comply with the HONcode standard for trustworthy health information. Avoid or Use Alternate Drug. Accessed: 4/12/2011. Where: Medicine concentration Amount of active substance per a given volume of your drug. Minor/Significance Unknown. The dosing for iron replacement treatment in pediatric patients with HDD-CKD has not been established. 3) Auerbach M, Witt D, Toler W, Fierstein M, Lerner RG, Ballard H. (1988) Clinical use of the total dose intravenous infusion of iron dextran. Maintain a well-balanced diet, and follow any dietary guidelines as directed by your doctor. There is limited experience with administration of an infusion of 500 mg of Venofer, diluted in a maximum of 250 mL of 0.9% NaCl, over a period of 3.5 to 4 hours on Day 1 and Day 14. Intravenous therapy is preferred for urgent intervention and when oral iron cannot be absorbed or the patient suffers from chronic renal impairment. Applies only to oral form of both agents. Situation Analysis Market Size MAT Sales Cr LC MAT Share % MAT Gr % Total Pharma Market 9388.69 100 13.5 Iron Sucrose 11.18 93.81 37.65 Brand Company Saline MAT . Both the 200- and 300-mg doses of IV iron sucrose administered over 2 hours appear to be safe. Minor/Significance Unknown.iron sucrose increases levels of calcium carbonate by enhancing GI absorption. Venofer (iron sucrose injection, USP) is a brown, sterile, aqueous, complex of polynuclear iron (III)- . Venofer (iron sucrose injection, USP) For Intravenous Use Only INDICATION AND USAGE Venofer (iron sucrose injection, USP) is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). iron sucrose decreases levels of methyldopa by inhibition of GI absorption. Do not administer Venofer to patients with iron overload. For adult CKD patients on ESA therapy who are not receiving iron supplementation, the guideline suggests a trial of IV iron (or in NDD-CKD patients, alternatively, a 1- to 3-month trial of oral iron therapy) if: CKD=chronic kidney disease ESA=erythropoietin-stimulating agent Hb=hemoglobin IV=intravenous RBC=red blood cell WBC=white blood cell. A patients lean body weight (or actual body weight if less than lean body weight) should be utilized when determining dosage. Deferiprone may bind polyvalent cations (eg, iron, aluminum, and zinc), separate administration by at least 4 hr between deferiprone and other medications (eg, antacids), or supplements containing these polyvalent cations. Iron Deficiency Calculator sodium sulfate/potassium sulfate/magnesium sulfate decreases levels of iron sucrose by inhibition of GI absorption. In: Koda-Kimble & Young's Applied Therapeutics: The Clinical Use of Drugs. Consult your doctor before breast-feeding. . Copyright 2014 - 2023 The Calculator .CO |All Rights Reserved|Terms and Conditions of Use, Parenteral Iron Replacement For Iron Deficiency Anemia Calculator, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Clinical use of the total dose intravenous infusion of iron dextran, When is high-dose intravenous iron repletion needed? Serious - Use Alternative (1)iron sucrose will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. Serious - Use Alternative (1)iron sucrose decreases levels of mycophenolate by inhibition of GI absorption. Schweiz Med Wochenschr; 100(7):301-3. Here are the steps to follow for using this drug dosage calculator: First, enter the value of your Weight and choose the unit of measurement from the drop-down menu. Monitor Closely (1)iron sucrose decreases levels of penicillamine by inhibition of GI absorption. Avoid or Use Alternate Drug. IV iron products (adults) - UpToDate Avoid or Use Alternate Drug. Administer ciprofloxacin at least 2 hours before or 6 hours after using these products. Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. Applies only to oral form of both agents. Dosage Calculator - [100% Free] - Calculators.io Venofer can be given as a maximum of 200mg not more than 3 times per week; doses must be 24 hours apart. This site complies with the HONcode standard for trust- worthy health information: verify here. Data from Ferrlecit postmarketing spontaneous reports indicate that individual doses exceeding 125 mg may be associated with a higher incidence and/or severity of adverse events. The dosing for iron replacement treatment in pediatric patients with NDD-CKD or PDDCKD has not - been established. Adult Patients with Hemodialysis Dependent-Chronic Kidney Disease (HDD-CKD): Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session. Administer on 5 different occasions over a 14 day period. Normal haemoglobin values are gender specific: for males from 13.8 to 18.0 g/dL (138 to 180 g/L, or 8.56 to 11.17mmol/L) and females from 12.1 to 15.1 g/dL (121 to 151 g/L, or 7.51 to 9.37mmol/L). iron sucrose decreases levels of ibandronate by inhibition of GI absorption. Individual plans may vary Use Caution/Monitor. iron sucrose decreases levels of minocycline by inhibition of GI absorption. Test Dose: Not required. Administer ciprofloxacin at least 2 hours before or 6 hours after using these products. PDF PRODUCT MONOGRAPH - pdf.hres.ca Human studies not conducted. Applies only to oral form of both agents. Applies only to oral form of both agents. Prior to and at regular intervals during parenteral iron therapy, evaluate serum iron, hemoglobin, and hematocrit. Corrected Sodium and Effective Osmolality. The dosing for iron replacement treatment in pediatric patients with Peritoneal or Hemodialysis-Dependent - CKD or Non-Dialysis Dependent CKD have not been established. Nutr Clin Pract. Applies only to oral form of both agents. This information is not individual medical advice and does not substitute for the advice of your health care professional. Intravenous therapy is usually recommended in case of contraindications to oral iron, comorbidities that prevent absorption, chronic renal impairment or iron replacement needs to be rapid. Coadministration of ciprofloxacin with multivalent cation-containing products may reduce the bioavailability of ciprofloxacin by 90%. Iron Sucrose Dosage Guide + Max Dose, Adjustments - Drugs.com informational and educational purposes only. 5. The dosage of iron sucrose is expressed in mg of elemental iron. Administer Venofer only intravenously by slow injection or by infusion. Applies only to oral form of both agents. Discard unused portion. Intravenous (IV) iron products (use in adults) Dosing information in this table is for adults and includes some dosing recommendations not listed in the approved product information. prescription products. Assessing new treatment options. Pasricha SR, Flecknoe-Brown SC, Allen KJ, Gibson PR, McMahon LP, Olynyk JK, Roger SD, Savoia HF, Tampi R, Thomson AR, Wood EM, Robinson KL. 2010;18(3). Recommended dosage for patients weighing less than 50kg (110lb): Give Injectafer in This parenteral iron replacement for iron deficiency anemia calculator determines the parenteral dose of iron supplement needed to replenish iron stores and hemoglobin levels. Minor (1)iron sucrose decreases levels of manganese by inhibition of GI absorption. Applies only to oral form of both agents. In key trials, ferric carboxymaltose increased Hb levels and replenished iron stores as effectively as IV iron sucrose . Applies only to oral form of both agents. PDF Protocol for the use of Intravenous Iron Sucrose (Venofer Monitor for signs and symptoms of hypotension following each Feraheme infusion. Venofer treatment may be repeated if necessary. Monitor Closely (1)iron sucrose will decrease the level or effect of omadacycline by inhibition of GI absorption. OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Hemoglobin can be input in g/dL, g/L or mmol/L and refers to the amount of hemoglobin in the red blood cells. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Minor/Significance Unknown. Intravenous iron-dextran: therapeutic and experimental possibilities [in German] Schweiz Med Wochenschr. Initial symptoms may include hypotension, syncope, unresponsiveness, cardiac/cardiorespiratory arrest. J Lab Clin Med. FERAHEME was non-inferior to Venofer (iron sucrose) in mean Hgb rise from baseline 2,5. Applies only to oral form of both agents. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. Fulminant symptoms include confusion, sensation of passing out, paleness. The usual total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. Minor/Significance Unknown. Monitor Closely (1)sodium bicarbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Use Caution/Monitor. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. Minor/Significance Unknown. Prescribing and dispensing information For iron sucrose A complex of ferric hydroxide with sucrose containing 2% (20 mg/mL) of iron. Equations used: 1] Calculation of the Total Iron Deficit: Total iron deficit [mg] = body weight [kg] x (target Hb-actual Hb) [g/dl] x 2.4 + depot iron [mg]. We have found the lower dose to be better tolerated in the second half of gestation. David McAuley, Pharm.D. 4)Pasricha SR, Flecknoe-Brown SC, Allen KJ, Gibson PR, McMahon LP, Olynyk JK, Roger SD, Savoia HF, Tampi R, Thomson AR, Wood EM, Robinson KL. Do not administer Venofer to patients with evidence of iron overload. Hemoglobin there are two fields for hemoglobin input, one for the target and another for actual value. Ren Fail. WARNING: RISK FOR SERIOUS HYPERSENSITIVITY/ANAPHYLAXIS REACTIONS Fatal and serious hypersensitivity reactions including anaphylaxis have occurred in patients receiving Feraheme. rabeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Compare formulary status to other drugs in the same class. . 2) Koch TA, Myers J, Goodnough LT. (2015) Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. Copyright 2021 GlobalRPH - Web Development by. 2. Calculosaurus | Ferinject dose calculator Applies only to oral form of both agents. calcium chloride decreases levels of iron sucrose by inhibition of GI absorption. Iron Deficiency in Heart Failure - Home - American College of Cardiology iron sucrose, benazepril. Applies only to oral form of both agents. Iron Injection Administration | INJECTAFER HCP Monitor Closely (1)iron sucrose decreases levels of deferiprone by enhancing GI absorption. Iron supplements, regardless of their way of administration, are used to replete body stores and to correct anemia. Serious - Use Alternative (1)iron sucrose decreases levels of oxytetracycline by inhibition of GI absorption. Ferric gluconate: 12.5 mg/mL Schrier SL, Mentzer WC, Landaw SA. You may need extra iron because of blood loss during kidney dialysis. sodium citrate/citric acid will decrease the level or effect of iron sucrose by increasing gastric pH. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. There are physiological variation in iron reserves such as the decrease during menstruation period. Monitor Closely (1)lansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Iron deficiency anemia is the type of anemia caused by iron depletion. https://www.uptodate.com/ (Requires subscription). The above information is provided for general iron sucrose, captopril. Use Caution/Monitor. Monitor Closely (1)iron sucrose decreases levels of ibandronate by inhibition of GI absorption. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Injectafer treatment may be repeated if iron deficiency anemia reoccurs. The following table present normal hemoglobin ranges: There is another equation for iron deficit that can be used to calculate replenishment needs, that of Ganzoni, which takes into account iron stores as well and that can be found in the iron deficit calculator. Applies only to oral form of both agents. STORAGE: Consult the product instructions and your pharmacist for storage details. There are four variables, all patient parameters, required in the iron deficiency calculator: The patients weight is used in the Ganzoni equation and also when establishing the iron stores. Minor/Significance Unknown. famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Iron Deficiency Calculator - MDApp Calculation of Dosage of Nefrofer Total Iron Deficit (mg) Nefrofer (ml) = 20mg/ml Total Iron Deficit (mg) = Body weight (kg) x (Target Hb - Actual Hb) [g/l] x 0.24* + Depot Iron . Venofer (iron sucrose) Uses, Dosage, Side Effects - Drugs.com Fatal reactions have also occurred in situations where the test dose was tolerated. Symptoms associated with Venofer total dosage or infusing too rapidly included hypotension, dyspnea, headache, vomiting, nausea, dizziness, joint aches, paresthesia, abdominal and muscle pain, edema and cardiovascular collapse. 1970;100(7):301303. Fulminant symptoms may include general paleness, confusion or episodes of passing out. Before using, check this product visually for particles or discoloration. Applies only to oral form of both agents. J Med. Maximum single dose of iron sucrose to be given at a time in Non-dialysis CKD patients is 500 mg but with limited experience. *Repeat dose if iron deficiency anemia reoccurs. The plasma ferritin level as a reliable index of body iron stores following intravenous iron dextran. It is usually given slowly over 2 to 5 minutes or as directed by your doctor. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Use Caution/Monitor. Excessive dosages of Venofer may lead to accumulation of iron in storage sites potentially leading to hemosiderosis. Applies to didanosine chewable tablets and powder for oral solution; administer 2 hr before or several hours after didanosine oral solution or chewable tablet administration. Do Not Copy, Distribute or otherwise Disseminate without express permission.
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